![]() Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology. TXA decreased epidermal pigmentation associated with melasma and also reversed melasma-related dermal changes, such as vessel number and increased numbers of mast cells. Type IV collagen staining was not observed in all specimens. One 2019 study explored the benefits of two different treatments for melasma, a common skin condition that can cause brown or gray patches of discoloration on the face. Histological analysis showed significant reduction of epidermal pigmentation, vessel numbers and mast cell counts. The erythema index scores of lesional and perilesional skin also showed a similar pattern. Interestingly, the MI scores for the perilesional skin increased. The mean lesional melanin index (MI) scores decreased significantly. Twenty-two subjects completed the study and no serious adverse events occurred during the study period. Fontana-Masson, anti-CD31, antitryptase and antitype IV collagen staining was performed. Skin pigmentation and erythema was measured using a Mexameter(®) during each visit and skin biopsies were collected from eight subjects before and 8 weeks after treatment. Volunteers were instructed to take two TXA tablets three times a day and apply a TXA topical agent twice a day for 8 weeks. To elucidate the effects of oral and topical TXA on melasma.Ī clinical study was conducted with 25 women for 8 weeks from March to July 2010. However, the effects of oral and topical TXA on melasma have not been well studied and the underlying mechanism remains unclear. Tranexamic acid (TXA), a plasmin inhibitor, is reported to improve melasma when injected locally. It is common, harmless and some treatments may help. Melasma happens because of overproduction of the cells that make the color of your skin. Melasma is associated with epidermal hyperpigmentation, weak basement membrane, vascular proliferation and increased numbers of mast cell. Melasma is a skin condition characterized by brown or blue-gray patches or freckle-like spots.
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